Blar i forfatter "Olsen, Elisabeth Klungerbo"

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    • Bioprospecting of Arctic marine organisms Employing bioassay-, chemistry-, and metabolomics-guided isolation 

      Olsen, Elisabeth Klungerbo (Doctoral thesis; Doktorgradsavhandling, 2015-09-25)
      The marine environment inhabits a large diversity of organisms that produce natural products as a strategy for survival. Many marine natural products are found to display different bioactivities and some of them have reached the market as drugs or dietary supplements. Comprehending the great potential of bioactive marine natural products motivates for the continuing bioprospecting of organisms from ...

    • Cellular Antioxidant Effect of Four Bromophenols from the Red Algae, Vertebrata lanosa 

      Olsen, Elisabeth Klungerbo; Hansen, Espen; Isaksson, Johan; Andersen, Jeanette hammer (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Three known bromophenols, 2,3-dibromo-4,5-dihydroxybenzylaldehyde (1), 2,2′,3-tribromo-3′,4,4′,5-tetrahydroxy 6′-hydroxymethyldiphenylmethane (2) and bis(2, 3-dibromo-4,5-dihydroxylbenzyl) ether (3), and one new one, 5,5″-oxybis(methylene)bis (3-bromo-4-(2′,3′-dibromo-4′,5′-dihydroxylbenzyl)benzene-1,2-diol) (4), were isolated from an extract of the red alga, Vertebrata lanosa. The antioxidant ...

    • Synthetic analogs of stryphnusin isolated from the marine sponge Stryphnus fortis inhibit acetylcholinesterase with no effect on muscle function or neuromuscular transmission 

      Moodie, Lindon; Zuzek, Monika; Frangez, Robert; Andersen, Jeanette hammer; Hansen, Espen; Olsen, Elisabeth Klungerbo; Cergolj, Marija; Sepcic, Kristina; Hanssen, Kine Østnes; Svenson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-09)
      The marine secondary metabolite stryphnusin (1) was isolated from the boreal sponge Stryphnus fortis, collected off the Norwegian coast. Given its resemblance to other natural acetylcholinesterase antagonists, it was evaluated against electric eel acetylcholinesterase and displayed inhibitory activity. A library of twelve synthetic phenethylamine analogs, 2a–7a and 2b–7b, containing tertiary and ...